Tailor both the resume and cover letter. How many times have you heard people say they customize their cover letter, but send the same resume to everyone? Usually they are very proud of themselves for doing this, as many job seekers send one form letter and resume to everyone. Unfortunately, when a resume is competing with 200 to 400 others, it has to stand out from the crowd. Recruiters don't have time to separate the "diamonds from the dirt" in the 10 to 60 seconds they spend skimming for relevant experience. It is the candidate's responsibility to sort the valuable stuff from the extraneous, using only 20-carat material to land an interview.

To succeed in life in today's world, you must have the will and tenacity to finish the job.
Chin-Ning Chu

It is extremely unlikely that anyone coming out of school with a technical degree will go into one area and stay there. Today's students have to look forward to the excitement of probably having three or four careers.
Gordon Moore