If your resume will be read by a resume scanning program for key words, it's absolutely imperative that those key words be included in your text. Consequently, tailoring your resume to an ad, networking recommendation or job description is probably even more important than if a person were doing the initial screening. In this respect people-scanned and computer-scanned resumes are very similar. However, because some computer scanners have difficulty reading vertical lines, italics and unusual type fonts, techniques you might use to grab the attention of recruiters can be misinterpreted by a computer. If your resume is likely to be scanned, keep the format simple and use only boldface type and bullets to highlight major points.

Successful people begin where failures leave off. Never settle for 'just getting the job done.' Excel!
Tom Hopkins

Replying to all resumes would be the polite thing to do, but often it simply isn't practical. If a company receives 200 responses for an ad, or experiences a continual deluge of unsolicited resumes, it would spend an inordinate amount of time sending acknowledgments. If you really want a receipt for your resume, send a stamped, self-addressed postcard asking for one. If you make it easy, the human resources department will comply.